Current positions open in the laboratory:
Post-doctoral Position (early discovery)
Description: The candidate will act as a full-time post-doctoral researcher to study mechanisms of response and resistance to immunotherapy in cancer. The liver is one fundamental determinant of the efficacy of immunotherapy and is a key organ involved in metastasis. In this position, the candidate will study determinants regulated by the liver that influence metastasis and immunosurveillance in cancer. They will incorporate multiple strategies to study this biology including antibody and small molecule drugs, cellular therapy (e.g. CAR T cells) and genetic therapy (e.g. AAV vectors). The candidate will have the opportunity to undertake and learn many skills including: 1) the application of novel animal models of cancer and 2) multidimensional analyses of T cell and myeloid cell biology using transcriptional, flow cytometry, and multiplex IHC/IF techniques. The candidate will learn fundamentals of immunobiology in cancer, state-of-the-art approaches to understanding immune mechanisms of resistance and response, and key principals in applying basic science research to inform clinical investigation.
Qualifications: Applicant should have a MD, PhD or both with a background in immunology, cancer biology, or cellular biology. Experience with general techniques in cellular biology, histology, flow cytometry, and the conduct of animal experiments (including surgical procedures) is preferred. Outstanding writing/communication skills and strong motivation are required. Meticulous record keeping skills are essential for this position. The applicant should have a high quality publication record and will be expected to apply for funding during the course of their training.
Post-doctoral Position (translational discovery)
Description: The candidate will act as a full-time post-doctoral researcher to study the "immune connectome" in tumors. Within the tumor microenvironment, immune cells engage in dynamic and multiple interactions with many cells which determine their ultimate fate. Tumors are remarkably heterogeneous and establish multiple unique communities. The biology and relevance of these spatially distinct environments, though, is poorly understood. In addition, little is known about the capacity to shift the "immunological state" of these communities to favor productive immune surveillance and to suppress tumor growth and metastasis. This knowledge would have remarkable implications for designing novel treatment paradigms for improving therapeutic outcomes. We have developed many of the multidimensional and spatial analysis tools necessary to interrogate this biology. In this position, the candidate will study this biology using human tissue specimens and tissues derived from animal models. Studies will involve the use of multi-dimensional flow cytometry, CyTOF, RNA sequencing, multi-plex IHC/IF, and image analysis software. The candidate will have the opportunity to learn cutting-edge skills and knowledge in the spatial biology of tumors. The candidate will learn fundamentals of immunobiology in cancer, state-of-the-art approaches to understanding immune mechanisms of resistance and response, and key principals in applying basic science research to inform clinical investigation.
Qualifications: Applicant should have a MD, PhD or both with a background in immunology, cancer biology, cellular biology, or bioinformatics. Experience with general techniques in cellular biology, histology, flow cytometry, and the conduct of animal experiments (including surgical procedures) is preferred. Outstanding writing/communication skills and strong motivation are required. Meticulous record keeping skills are essential for this position. The applicant should have a high quality publication record and will be expected to apply for funding during the course of their training.
PhD and MD/PhD Graduate students interested in positions to study basic mechanisms of immunobiology (involving myeloid cells and T cells) in cancer are welcome to apply for positions in the laboratory at any time. Qualifications: All students will be expected to write for student fellowship applications.
